Ms. Rwakairu, the niece to the former presidential candidate and Prime Minister Mbabazi, was raised as his daughter after the death of her father.
She will be walking down the aisle with Mr. Ramaphosa later this year, according to her family.
Read Also: I'm rich & tired of singing - Weasel
A traditional function is expected to be held on Saturday, 19th May at the former Prime Minister's home Kololo.
The South African president has had a healthy relationship with the East African country ever since his first visit in 2004 when he got interested in the long horned Ankole cows from the western part of the country.
He bought some cows but couldn't not import them to South Africa -- he instead imparted some embryos and now he is the country's largest Ankole cows farmer.
Family vacation in Uganda
Ramaphosa and his family secretly visited Uganda's wildlife sanctuaries. The family trekked mountain gorillas.